The Louisiana Purchase nearly doubled the land mass of the United States and opened the area for settlement. St. Louis was the "gateway" to this new land. The "little Dixie" highway, the Boone's Lick Trail, the El Camino Real and the Missouri River took those looking for a better life, or just plain old adventure, to the new towns that began to spring up along the way. Some stayed and caused these towns to grow. Others passed on through. Below are some of those towns that were established during that time period. Many of them would make an enjoyable day-trip for the history as well as for the annual events that these towns hold. Check them out!