The community of Defiance, Missouri is located in St. Charles County in the 63341 Zip Code area. It is an unincorporated community and officially a "Census Designated Place", rather than a village or city. Defiance is located on Highway 94, just west of the Missouri River.
The Katy Trail, a Missouri State "rails to trails" biking and hiking trail, can be easily accessed in Defiance. It is a great place to stop for refreshments during a day of biking or to stay awhile and spend the night at the local Bed and Breakfast.
Defiance is on the Missouri Wine Trail and has several wineries, as well as being close to several others. Chandler Hill Vineyards and Sugar Creek Winery are the wineries found in Defiance. Mount Pleasant Winery, Montelle Winery, Balducci Vineyards and Noboleis Vineyards are found just down Highway 94 in Augusta.