St. George, Missouri is located in South St. Louis County, in the 63123 Zip Code area, about 15 minutes south of Downtown St. Louis via Interstate 55. Important roads for the community are Reavis Barracks Road, Interstate 55, Huntingdon and Zenith Drive. St. George was officially incorporated in 1948. In November 2011, citizens of the City of St. George Missouri voted to un-incorporate the city and it passed. The "city" of St. George is no longer and is now part of unincorporated South St. Louis County.
The community is served by the Affton School District and the Mehlville School District.