The Mark Twain/I-70 Industrial Neighborhood is located along the northwestern edge of the City Limits of St Louis. The borders for the neighborhood are Interstate 70 to the north, Kingshighway and the western edge of Penrose Park to the east, Natural Bridge Avenue to the south and the City Limits to the west. Surrounding neighborhoods are the Walnut Park West, Walnut Park East and Mark Twain neighborhoods to the north, the Penrose Neighborhood to the east, and the Wells-Goodfellow and Kingsway West neighborhoods to the south. St. Louis County and the City of Hillsdale are located to the west.
The majority of the Mark Twain/I-70 Industrial Neighborhood is covered by industrial areas. A small section, west of Goodfellow, has a nice residential subdivision with neat brick homes. These residents are served by the St. Louis Public School District. Although none of the district's schools are located in the Mark Twain/I-70 Industrial Neighborhood, several are located in the nearby neighborhoods. Those include the Laclede Elementary and Langston Middle schools in the Wells/Goodfellow Neighborhood. The Lexington Elementary School in the Kingsway West Neighborhood. The Northwest Academy of Law High School and the Walbridge Elementary School in the Walnut Park East Neighborhood. And the Ashland Elementary School in the Penrose Neighborhood on North Newstead. The City Academy, a private independent elementary school, is located in the Mark Twain/I-70 Industrial Neighborhood on North Kingshighway. The private St. Matthew Lutheran School is located on Wren Avenue in the Walnut Park East Neighborhood.
Penrose Park, one of the City's 111 parks, straddles Kingshighway and provides the area with many recreation options. One of its unique features is a Velodrome. What is a "velodrome?" It is a track that can be indoor or outdoor and is banked for bicycle riding and races. The Penrose Park Velodrome is the only one found at any of the City parks, in fact, the Penrose Velodrome is the only one in Missouri and one out of only 27 that are found in the nation! Other amenities are athletic fields for baseball and softball, courts for tennis, basketball and handball, a playground and picnic pavilions. The Matthews-Dickey Boys and Girls Club is found in the neighborhood, located across from Penrose Park on the west side of Kingshighway. The Barrett Brothers Park, a 13 acre park located in the Wells/Goodfellow Neighborhood provides fields for baseball, softball and soccer, a playground and picnic facilities and a pavilion. Another City park is the Dwight Davis Park in Walnut Park East that features 9.6 acres of parkland, a playground, a basketball court, soccer, softball and baseball fields, a multi-purpose court, tennis courts, a fun spray pool and more.
Conveniently located for the residents of the neighborhood are the Walnut Park Branch Library on West Florissant Avenue and the Julia Davis Branch Library on Natural Bridge Avenue, two of the 15 branches of the St. Louis Public Library system.