The Kings Oak Neighborhood is located just south of Forest Park. The neighborhood gets its name from two of its boundary streets, Kingshighway and Oakland. The boundaries are Oakland Avenue to the north, Kingshighway to the east, Manchester Road to the south and Macklind to the west. Surrounding neighborhoods include the Forest Park Southeast Neighborhood to the east, Cheltenham to the west and Ellendale to the south. Forest Park, the "jewel" of the St. Louis City Parks system, lies to the north of Kings Oak.
The St. Louis Public School District serves the residents of the Kings Oak Neighborhood. One district school is located there, Compton-Drew Investigative Learning Center Middle School. Compton Drew, a magnet school, was built in 1996 and provides education for grades 6th through 8th with a focus on Math, Science and Technology. Another school is located in the neighborhood, St. Louis University High. It is a private all boys Catholic college preparatory high school. St. Louis University High was founded in 1818 along with St Louis University as the University's high school department. St. Louis University High separated itself from the University when it moved to its present location in the Kings Oak Neighborhood in 1924.
The St. Louis Science Center is a prominent resident of the Kings Oak Neighborhood and can be seen from Interstate 64. The Science Center's main building on Oakland Avenue was opened in 1991. The James S. McDonnell Planetarium, the Science Center's previous home, is located in Forest Park and accessible by an enclosed walkway over the Interstate.